What is the Endocannabinoid System?
The Endocannabinoid System is a system of neurotransmitters that is naturally found in every human’s body. There are two main receptors that THC can bind to – which determines the effects cannabis edibles can offer.

• CB1 Receptors: Offer more cerebral effects such as brain activity, memory, and appetite.
• CB2 Receptors: Offer more bodily effects such as pain relief, organ improvement, and immune system strengthening.

Generally speaking, it is common to find more Sativa-dominant products will bind to the CB1 receptors, whereas more Indica-dominant products will bind to the CB2 receptors. Each offering their respective benefits.

How do Edibles work?
Edibles are cannabis-infused foods, drinks, or candies that are consumed to achieve the desired effects in the body. Unlike smoking cannabis, edibles require an activation time that can range from 20-60 minutes on average. Typically, effects last longer than other consumption methods since the edible needs to be broken down through the digestive system.

Edible Recommendations
When determining what edibles to choose, or how many to take, there are questions to consider:

• What do you want to eat?
• What is your tolerance with edibles?
• What strength do you want?

The Makery, for example, offers gummies and cookies. The first and simplest question is: which do you prefer? From there, the next step is to determine proper dosing. A beginner with edibles should always start at the lowest milligram available – often 5mg to 10mg. If you are somebody that is comfortable with edibles, however, then there are also 25mg options available in various gummy flavors. ( Only available in MA )

Important to Remember
With edibles, it is always important to remember two key phrases:

• Start low and go slow.
• You can always eat more, but you can’t eat less.

Edibles can be tricky, due to their activation period. It can vary based on height, weight, metabolism speed, amount of physical activity, or what was eaten that day. The most common mistake anybody can make is assume the edible didn’t work, and they eat more – then multiple edibles kick in at once and cause over consumption.

Stay informed and be patient with your experience. That’s the recipe for success with edibles.